There has been major growth in understanding immune suppression mechanisms and their relationships to cancer progression and therapy. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumoral immune suppression. The second edition of Cancer Immunotherapy highlights emerging principles of immune suppression that drive cancer and offers new ideas about how therapy can be improved by attacking these principles. Beginning by reviewing current understanding of cancer immunobiology and therapeutics, the book moves into a deep examination of cancer immunosuppression and how it might be defeated. These chapters cover topics such as dendritic cells and co-inhibitory molecules, regulatory T-cells, tumor-associated macrophages, myeloid-derived suppressor cells, and factors in immune escape. Authored by two internationally recognized leaders in cancer biology and immunology, this book provides basic, translational, and clinical cancer researchers an indispensable overview of immune escape as a critical trait in cancer, and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease. •Synthesizes concepts that are useful to both cancer immunologists and pharmacologists •Summarizes the latest insights into how immune escape defines an essential trait of cancer •Includes numerous illustrations to clarify advanced concepts
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September 25, 2013
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