His Brother's Keeper: A Story from the Edge of Medicine
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Overview
From Jonathan Weiner, Pulitzer Prize-winning author of The Beak of the Finch, comes His Brother's Keeper -- the story of a young entrepreneur who gambles on the risky science of gene therapy to try to save his brother's life. Stephen Heywood was twenty-nine years old when he learned that he was dying of ALS -- Lou Gehrig's disease. Almost overnight his older brother, Jamie, turned himself into a genetic engineer in a quixotic race to cure the incurable. His Brother's Keeper is a powerful account of their story, as they travel together to the edge of medicine. The book brings home for all of us the hopes and fears of the new biology. In this dramatic and suspenseful narrative, Jonathan Weiner gives us a remarkable portrait of science and medicine today. We learn about gene therapy, stem cells, brain vaccines, and other novel treatments for such nerve-death diseases as ALS, Alzheimer's, and Parkinson's -- diseases that afflict millions, and touch the lives of many more.
Editorial Reviews
At the heart of this report from the front lines of gene therapy and other regenerative medicine techniques lies a simple, heartbreaking question: "What would you do to save your brother''s life " When Stephen Heywood, a 29-year-old carpenter, was diagnosed with amyotrophic lateral sclerosis (also known as Lou Gehrig's disease), his older brother, Jaime, launched his own research project to search for a cure. It was the late 1990s, shortly after scientists had cloned a living creature for the first time. So when Jamie told a friend about research demonstrating that the DNA of every ALS victim was missing a protein, his response ("Why don't you just put the damn protein back ") seemed wildly optimistic but not entirely impossible-if they could figure out how to do it in time. Weiner (The Beak of the Finch) keeps the actual science to a minimum. The story's power derives from attention to small, human details, like Stephen's first symptoms of losing strength in his fingers. The emotional register is also strong; Weiner spends so much time with the Heywoods that they begin to refer to him as one of the family, and his closeness allows him to effectively contrast their handling of Stephen's condition to his own family's reaction to his mother's bout with a similar nerve-death disease. Weiner can't give readers a happy ending for Stephen, but he can-and does-offer a powerful account of equal parts ambition and hope. (Mar.) Forecast: Weiner's The Beak of the Finch won the Pulitzer and his Time, Love, Memory won the NBCC Award. Also, Weiner has a five-city tour plus additional lecture tie-ins, as well as other national media planned. Copyright 2004 Reed Business Information. -- PUBLISHERS WEEKLY.
Author Information
Bio of Jonathan Weiner
Jonathan Weiner's books have won the Pulitzer Prize, the National Book Critics Circle Award, the Los Angeles Times Book Prize, and many other honors. While working on His Brother's Keeper, he was writer-in-residence at Rockefeller University. He lives in Bucks County, Pennsylvania, with his wife and their two sons.
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Additional Info
Imprint
HarperCollins
Filesize
715.55 KB
Number of Pages
384
eBook ISBN
9780061156595
Awards
- Los Angeles Times Book Prizes
- New York Times Notable Books of the Year
Excerpt from: His Brother's Keeper by Jonathan Weiner
Chapter One
Portents
When they were boys, Jamie and Stephen Heywood loved to arm wrestle. They made it a ritual: first the right arm, then the left, then, if there was time, a wrestling match on the rug. Their rules of engagement were so complicated and so long unspoken that no one else ever learned the game. Even Jamie's best friend Duncan Moss did not know how to play. Duncan would take one step across the line on the rug. Then he would see the look on Jamie's face.
What? What did I do?
He did not know the rules.
The Heywoods lived in an old house on Mill Street in Newtonville, Massachusetts, a suburb of Boston. All three of the Heywood boys, Jamie, then Stephen, and then the youngest, Ben, were athletic dreamers, inventors of many rituals and adventures. The house on Mill Street is a block from a patch of woods and a pond. The brothers played football there in a corner field that belonged to a neighbor they called Aunt Betsy. Late at night when it rained hard, Jamie and Stephen snuck out with boogie boards. They hopped a fence to the creek, which got roaring in a good storm. Through the dark and the rain they rode the rapids into Bolough's Pond.
Their parents, Peggy and John Heywood, are well known in Newtonville. They love traditions, too. Each of them has served terms as Senior Warden of Grace Church, in Newton Corners. When their boys were young, they went back every summer to the dairy farm in South Dakota where Peggy had grown up. She had won a full scholarship to Radcliffe, in Cambridge, which is where she met John. Peggy worked as a therapist; she kept her practice small and devoted herself to the family.
Every seven years, they spent a year in England, where John was born and raised. John Heywood is a professor of mechanical engineering at the Massachusetts Institute of Technology, and an international authority on internal combustion engines. He is the son of a British coal engineer who turned to solar power early on, back when only the cranks were interested in what he had to say -- back when a maverick who worried about coal smoke, soot, and acid, and praised the power of the sun, was like a bolt from the future. John Heywood consults about energy efficiency for Ford in Detroit, Ferrari in Italy, Toyota in Japan. When he is at home, he runs MIT's Sloan Automotive Laboratory, to which he commutes from Mill Street on a bicycle.
Each summer in July or August, Peggy's side of the family gathered from across the country for a reunion at the beach town of Duck, near Kitty Hawk, in the Outer Banks of North Carolina. A few of the children on the beach were always honorary Heywoods, as Aunt Betsy was an honorary aunt. John and Peggy, Jamie, Stephen, and Ben each brought friends. The boys swam, sailed, surfed, and raced on the cold shining track the waves made for them. Every summer on one of their last days at Duck they played a game of basketball with their cousins and with strangers they roped in from up and down the beach, wickedly violent games that routinely sent a few Heywoods to the hospital.
As Jamie and Stephen got older, they kept arm wrestling, ritually. In their late teens and early twenties, when the two and a half years between them no longer mattered, they were perfectly matched. But Jamie became a mechanical engineer, like their father and his father in England. Jamie was intelligent and driven, and spent his days and nights working at a desk. Stephen became a carpenter, a hands-on man like their mother's father and brother in South Dakota. Stephen was intelligent, too, but he mistrusted desks and ambitions. He spent a few years swinging a hammer on a framing crew, and his right arm became unbeatable.










